Youth Intensive Crème can be used day or evening, however it is most preferentially used as the final step of an evening regimen. The rich texture of this crème, along with its transformative activity, is most desirable in the evening when the skin is in its resting phase. Youth Intensive Crème contains mild mixed fruit acids that enable dead, dry skin to slough off, therefore individuals who are new to utilizing pharmaceutical grade skin care, or with a tendency to sensitivity should begin use gradually, 1-2 times per week. As the skin acclimates to the fast acting performance of iS Clinical, users may gradually increase use of the product to a level that is comfortable and best suited to individual skin goals. Those with younger, well-maintained skin who are using Youth Intensive Crème for age and damage prevention, or those who are less tolerant of daily hydroxy acid use, should settle in at using this product 1-3 times per week, based on their own skins behavior. Individuals with more mature and tolerant skin that is resistant and sun damaged can gradually upgrade use as they see fit, based on their skins behavior and skin goals. This product can also be used on other troublesome areas of the body. In any scenario, Youth Intensive Crème should not be used more than once daily and an iS Clinical SPF Protect product must be used in daytime and reapplied as needed when outdoors for extended periods of time.