The chemical structure of glycolic acid is the same in both formulas, where glycolic acid acts as an exfoliant. Other effects of the glycolic acid relate to the other ingredients being utilized as well as their amounts and interactions with other ingredients in the formula. Foaming Enzyme Masque System is a gentle, enzyme-based exfoliant that is easily tolerated. Intensive Resurfacing Masque contains other ingredients that affect its activity, including retinol and niacinamide.