Advance+ Vitamin C is a technologically advanced, newer form of Vitamin C that overcame the formulating disadvantages of first-generation Vitamin C. There are numerous formulating and user advantages to Advance+ Vitamin C, as it is compatible with copper, peptides, and various other ingredients that cannot be combined with the older first-generation Vitamin C. The first-generation Vitamin C formulations – which iS Clinical no longer uses – are not compatible with copper, many peptides, and other ingredients. Advance+ Vitamin C is better tolerated by the skin, has a time-release mechanism within skin cells, and is a more powerful ingredient.