Jewelry allergies or sensitivities related to nickel or copper alloys are to metallic nickel or copper. iS Clinical products contain no metallic copper or nickel. The ingredients Tripeptide-1 (Copper Tripeptide-1) and “Copper PCA” contain different forms of copper that are non-metallic and incorporated chemically (sheltered) within other molecules. Tripeptide-1 (Copper Tripeptide-1) is a short peptide composed of three amino acids complexed with copper. It is identical to a naturally occurring molecule, i.e. is “bioidentical”, within skin and other human cells used for tissue repair and synthesis of new, youthful collagen.