Pro-Heal Serum Advance+ is most commonly used in the morning, as the extremely high antioxidant levels can help protect against UV induced free radical damage. For high-grade acne and rosacea sufferers, Pro-Heal Serum Advance+ can be used both in the morning and evening. It is excellent for sensitive skin types and is good for all ages. It may also be dotted on insect bites to help inflammation.