No nano-sized particles or nano-encapsulated ingredients are used in iS CLINICAL products. Both Eclipse SPF50+ and Extreme Protect SPF30 sunscreens use micro-encapsulated sunscreen actives. Micro-encapsulated ingredients are larger in size than nano-encapsulated ingredients which are less than 200 micrometers (µm) in size. All iS Clinical sunscreens provide broad-spectrum protection against both UVA and UVB solar rays.