Hydrolyzed wheat protein is used in some iS Clinical products. It is chemically slightly different from wheat protein and reactions in those sensitive to gluten or wishing to avoid gluten is not expected. However, in any individual with severe gluten sensitivity, physician consultation is recommended before use of our products containing hydrolyzed wheat protein. We cannot assure the user that our individual ingredients are not exposed to any form of wheat protein during production and/or storage. A patch test would always be recommended for those having concerns about topical skin sensitivity.