Dermal pens, dermal rollers, or microneedling devices penetrate the skin barrier and may affect absorption of skin care products. iS Clinical products are designed to have excellent delivery and penetration to the site of action within the skin, and do not require the use of one of these devices for excellent results to be experienced. Some skin care practitioners, with their license qualifications, and after evaluating each client individually, decide to use iS Clinical products “off label” with these devices. Under these conditions, the product could be systemically delivered to areas deeper than the skin. These considerations could have importance to pregnant and nursing individuals. However, Cleansing Complex and SHEALD Recovery Balm may be incorporated into most post-procedure regimens.